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| 322 BC |
| | | Alexander's corpse, hijacked by Ptolemy, becomes a sacred relic in Alexandria | |
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| 317 BC |
| | | Philip III is killed on the orders of Olympias, the mother of Alexander | |
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| c. 310 BC |
| | | Alexander IV and his mother Roxana are murdered by order of Cassander (by now the self-proclaimed king of Macedonia) | |
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| 301 BC |
| | | Some 20 years after the death of Alexander the Great one of his generals, Ptolemy, extends his rule from Egypt to include Jerusalem | |
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| c. 300 BC |
| | | Phoenicia is brought into the new Hellenistic empire, changing hands frequently between contending successors of Alexander | |
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| 64 BC |
| | | The Seleucid dynasty ends when Syria, the last remnant ruled by his family, falls to the Romans | |
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| 30 BC |
| | | Cleopatra commits suicide, applying a poisonous asp to her breast, | |
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| 1409 |
| | | The Council at Pisa elects a new pope, Alexander V, without persuading the other two to resign - bringing the total to an unprecedented three | |
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| 1712 |
| | | Alexander Pope's Rape of the Lock introduces a delicate vein of mock-heroic in English poetry | |
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| 1789 |
| | | Alexander Mackenzie explores by canoe from central Canada through the Great Slave Lake to the Arctic Ocean | |
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